Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 8/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 10/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.51 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18284478 | 0.84 | CYP19A1 (0.64) | CYP19A1CYP3A4ESR1ESR2CYP1A2 | |
| SCHEMBL18284481 | 0.84 | CYP19A1 (0.64) | CYP19A1CYP3A4ESR1ESR2CYP1A2 | |
| SCHEMBL18284353 | 0.80 | CYP19A1 (0.74) | CYP19A1CYP3A4ESR1ESR2CYP1A2 | |
| SCHEMBL18284354 | 0.80 | CYP19A1 (0.74) | CYP19A1CYP3A4ESR1ESR2CYP1A2 | |
| SCHEMBL641722 | 0.80 | CYP19A1 (0.73) | CYP19A1CYP3A4ESR1ESR2CYP1A2 | |
| SCHEMBL641723 | 0.80 | CYP19A1 (0.73) | CYP19A1CYP3A4ESR1ESR2CYP1A2 | |
| SCHEMBL12468690 | 0.80 | CYP19A1 (0.73) | CYP19A1CYP3A4ESR1ESR2CYP1A2 | |
| SCHEMBL12134462 | 0.79 | PTGS2 (0.51) | CYP19A1CYP3A4ABCG2ESR1ESR2 | |
| SCHEMBL11260845 | 0.79 | ESR1 (0.66) | CYP19A1CYP3A4ESR1ESR2CYP1A2 | |
| SCHEMBL12134458 | 0.78 | CYP19A1 (0.67) | CYP19A1CYP3A4ESR1ESR2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063249-B1 | Substituted triphenyl butenes | OLEMA PHARMACEUTICALS, INC. (US) | 2011-11-22 | — | — | US | disclosed |