Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 5/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.50 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.47 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 4/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2724700 | 0.82 | AURKA (0.41) | MAP2K4MAPK1MAPKAPK2MAPK6FGFR1 | |
| SCHEMBL6643551 | 0.79 | BTK (0.48) | BTK | |
| SCHEMBL6116093 | 0.69 | BTK (0.65) | FGFR1BTKRPS6KA3 | |
| SCHEMBL15650052 | 0.67 | LRRK2 (0.41) | MAPK1BTK | |
| SCHEMBL11325 | 0.67 | PIK3CG (0.49) | MAP2K4MAPK1MAPKAPK2MAPK6FGFR1 | |
| SCHEMBL4200287 | 0.66 | IDO1 (0.71) | MAP2K4MAPK1MAPKAPK2MAPK6FGFR1 | |
| SCHEMBL13019158 | 0.65 | PIK3CG (0.47) | MYCWDR5ADORA2AADORA1 | |
| SCHEMBL1663652 | 0.65 | FGFR1 (0.68) | MAP2K4MAPK1MAPKAPK2MAPK6FGFR1 | |
| SCHEMBL2239527 | 0.64 | FGFR1 (0.52) | MAPK1FGFR1FGFR2PDPK1FGFR3 | |
| SCHEMBL5072725 | 0.64 | KDR (0.59) | MAP2K4MAPK1MAPKAPK2MAPK6FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491037-A1 | COMPOUNDS | Respivert Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048111-A1 | COMPOUNDS | RESPIVERT LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |