Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.68 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.68 |
| ▸ | MAP2K4 | P45985 | 7/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.62 |
| ▸ | MAPKAPK3 | Q16644 | 5/20 | 0.62 |
| ▸ | MAPK6 | Q16659 | 5/20 | 0.62 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.62 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.60 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.60 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | FER | P16591 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1663211 | 0.86 | AXL (0.60) | FGFR1FGFR2MAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL14359839 | 0.83 | MAP2K4 (0.62) | FGFR1FGFR2MAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL5378056 | 0.83 | DCLK1 (0.65) | FGFR1FGFR2MAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL10130802 | 0.78 | JAK2 (0.60) | FGFR1FGFR2MAP2K4MAPK1MAPKAPK3 | |
| Hydrochloric Acid SCHEMBL10369298 | 0.77 | JAK2 (0.58) | FGFR1FGFR2MAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL4006856 | 0.77 | AXL (0.55) | FGFR1FGFR2MAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL2469031 | 0.77 | AXL (0.55) | FGFR1FGFR2MAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL22801614 | 0.77 | MAP2K4 (1.00) | FGFR1FGFR2MAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL4029036 | 0.77 | MAP2K4 (0.67) | FGFR1FGFR2MAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL12193658 | 0.76 | MKNK1 (0.61) | FGFR1FGFR2MAPK1PDPK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |