Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | BACE1 | P56817 | 1/20 | 0.60 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.56 |
| ▸ | TCF7L2 | Q9NQB0 | 3/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27963381 | 0.90 | MAPT (0.64) | TP53MAPTBACE1THRBRXFP1 | |
| SCHEMBL5220867 | 0.86 | MAPT (0.62) | TP53MAPTBACE1THRBRXFP1 | |
| SCHEMBL4138365 | 0.86 | MAPT (0.62) | TP53MAPTBACE1THRBRXFP1 | |
| SCHEMBL4154829 | 0.84 | BACE1 (0.66) | TP53MAPTBACE1THRBRXFP1 | |
| SCHEMBL4135483 | 0.82 | BACE1 (0.68) | TP53MAPTBACE1THRBRXFP1 | |
| SCHEMBL4138847 | 0.81 | BACE1 (0.64) | TP53MAPTBACE1THRBRXFP1 | |
| SCHEMBL10330621 | 0.81 | MAPT (0.58) | TP53MAPTBACE1CTNNB1TCF7L2 | |
| SCHEMBL4142398 | 0.80 | BACE1 (0.66) | TP53MAPTBACE1THRBRXFP1 | |
| SCHEMBL4146923 | 0.80 | BACE1 (0.66) | TP53MAPTBACE1THRBRXFP1 | |
| SCHEMBL12693657 | 0.80 | MAPT (0.53) | TP53MAPTBACE1THRBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067608-B2 | Hedgehog pathway antagonists | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-8067608-B2 | Hedgehog pathway antagonists | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-11-29 | — | — | US | disclosed |
| US-20070232661-A1 | Hedgehog Pathway Antagonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-10-04 | — | — | US | disclosed |
| US-20070232661-A1 | Hedgehog Pathway Antagonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232661-A1 | Hedgehog Pathway Antagonists | GLI1, SHH, SMO | TP53 231/4885MAPT 3662/4885BACE1 2353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.