Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.62 |
| ▸ | TP53 | P04637 | 4/20 | 0.62 |
| ▸ | BACE1 | P56817 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | KLK7 | P49862 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138365 | 0.88 | MAPT (0.62) | MAPTTP53BACE1GAAMEN1 | |
| SCHEMBL27963381 | 0.88 | MAPT (0.64) | MAPTTP53BACE1GAAMEN1 | |
| SCHEMBL12693657 | 0.86 | MAPT (0.53) | MAPTTP53BACE1GAAMEN1 | |
| SCHEMBL12136807 | 0.86 | TP53 (0.64) | MAPTTP53BACE1GAAMEN1 | |
| SCHEMBL4154829 | 0.84 | BACE1 (0.66) | MAPTTP53BACE1GAAMEN1 | |
| SCHEMBL27803147 | 0.83 | MAPT (0.55) | MAPTTP53BACE1GAAMEN1 | |
| SCHEMBL4135635 | 0.81 | BACE1 (0.49) | MAPTTP53BACE1MEN1KMT2A | |
| SCHEMBL4144830 | 0.80 | MAPT (0.56) | MAPTTP53BACE1MEN1KMT2A | |
| SCHEMBL4129999 | 0.79 | HDAC1 (0.48) | MAPTBACE1THRBRXFP1MAPK1 | |
| SCHEMBL4137733 | 0.79 | BACE1 (0.47) | MAPTBACE1THRBRXFP1PTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009817-A1 | Substituted heteroaryls | INSTITUTES FOR PHARMACEUTICAL DISCOVERY, L.L.C. | 2005-01-13 | — | — | US | claimed |
| EP-1618094-B1 | SUBSTITUTED HETEROARYLS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES | INST FOR PHARM DISCOVERY INC (US) | 2007-09-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009817-A1 | Substituted heteroaryls | PTPRS, PTPRO, PTPRR | MAPT 1878/4885TP53 680/4885BACE1 1454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.