Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.46 |
| ▸ | NQO2 | P16083 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12137889 | 0.90 | KDM4E (0.44) | ADORA2AADORA1KDM4EADORA2BNQO2 | |
| SCHEMBL12137832 | 0.88 | KDM4E (0.45) | ADORA2AADORA1KDM4EADORA2BNQO2 | |
| SCHEMBL12137634 | 0.87 | AXL (0.56) | ADORA2AADORA1KDM4EADORA2BNQO2 | |
| SCHEMBL12138052 | 0.86 | ADORA2A (0.52) | ADORA2AADORA1KDM4EADORA2BNQO2 | |
| SCHEMBL12137676 | 0.86 | ADORA2B (0.59) | ADORA2AADORA1KDM4EADORA2BNQO2 | |
| SCHEMBL12137682 | 0.85 | KDM4E (0.45) | ADORA2AADORA1KDM4EADORA2BNQO2 | |
| SCHEMBL12137948 | 0.85 | ADORA2A (0.48) | ADORA2AADORA1KDM4EADORA2BCHUK | |
| SCHEMBL12138048 | 0.85 | CYP1A2 (0.49) | ADORA2AADORA1KDM4EADORA2BNQO2 | |
| SCHEMBL12137641 | 0.85 | NPY5R (0.55) | ADORA2AADORA1KDM4EADORA2BNQO2 | |
| SCHEMBL12137885 | 0.84 | ADORA2A (0.49) | ADORA2AADORA1RXFP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281838-A1 | 5-ALKYNYL-PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281838-A1 | 5-ALKYNYL-PYRIMIDINES | MKI67, CCNA1, CCNT1 | ADORA2A 314/4885ADORA1 87/4885KDM4E 1450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.