Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12143938 | 0.85 | SMN1; SMN2 (0.57) | ALDH1A1KMT2AL3MBTL1MEN1HPGD | |
| SCHEMBL16562180 | 0.85 | ALDH1A1 (0.69) | ALDH1A1KMT2AL3MBTL1MEN1HPGD | |
| SCHEMBL24635021 | 0.84 | KMT2A (0.53) | ALDH1A1KMT2AL3MBTL1MEN1GLA | |
| SCHEMBL13860776 | 0.83 | MAPT (0.62) | KMT2AMEN1HPGDEPHX2TP53 | |
| SCHEMBL9976045 | 0.83 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1HPGDTHRB | |
| SCHEMBL15682691 | 0.83 | MEN1 (0.53) | ALDH1A1KMT2AL3MBTL1MEN1POLB | |
| SCHEMBL20022976 | 0.82 | NPC1 (0.62) | ALDH1A1KMT2AMEN1TP53MAPT | |
| SCHEMBL15682711 | 0.82 | EPHX2 (0.58) | ALDH1A1HPGDEPHX2SMN1; SMN2POLB | |
| SCHEMBL11169677 | 0.82 | PPID (0.60) | ALDH1A1KMT2AL3MBTL1MEN1EPHX2 | |
| SCHEMBL9976043 | 0.81 | ALDH1A1 (0.42) | ALDH1A1KMT2AL3MBTL1MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204387-B1 | TRIAZOLOPYRAZINONES AS PDE1 INHIBITORS | H LUNDBECK AS (DK) | 2019-06-12 | — | — | EP | disclosed |
| US-10150771-B2 | Triazolopyrazinones as PDE1 inhibitors | H. LUNDBECK A/S (DK) | 2018-12-11 | — | — | US | disclosed |
| US-20170298072-A1 | Triazolopyrazinones as PDE1 Inhibitors | H. LUNDBECK A/S (DK) | 2017-10-19 | — | — | US | disclosed |
| EP-3204387-A1 | TRIAZOLOPYRAZINONES AS PDE1 INHIBITORS | H. Lundbeck A/S (DK) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016055618-A1 | TRIAZOLOPYRAZINONES AS PDE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2016-04-14 | — | — | WO | disclosed |
| US-8067420-B2 | Substituted pyrazinone melanin concentrating hormone receptor-1 antagonists and methods | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-11-29 | — | — | US | disclosed |
| US-8012984-B2 | Substituted pyrazinone melanin concentrating hormone receptor-1 antagonists and methods | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-09-06 | — | — | US | disclosed |
| US-20110144060-A1 | SUBSTITUTED PYRAZINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS AND METHODS | BRISTOL-MYERS SQUIBB COMPANY | 2011-06-16 | — | — | US | disclosed |
| US-20110003759-A1 | NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS AND METHODS | BRISTOL-MYERS SQUIBB COMPANY | 2011-01-06 | — | — | US | disclosed |
| WO-2009009501-A2 | NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS AND METHODS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-15 | — | — | WO | disclosed |
| US-20090011994-A1 | NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS AND METHODS | BRISTOL-MYERS SQUIBB COMPANY | 2009-01-08 | — | — | US | disclosed |
| US-20090011994-A1 | NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS AND METHODS | BRISTOL-MYERS SQUIBB COMPANY | 2009-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10150771-B2 | Triazolopyrazinones as PDE1 inhibitors | PDE5A, PDE4A, PDE12 | ALDH1A1 298/4885KMT2A 1246/4885L3MBTL1 3905/4885 |
| US-20170298072-A1 | Triazolopyrazinones as PDE1 Inhibitors | PDE5A, PDE4A, PDE12 | ALDH1A1 298/4885KMT2A 1246/4885L3MBTL1 3905/4885 |
| US-20110144060-A1 | SUBSTITUTED PYRAZINONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS AND METHODS | MCHR1, MC1R, MCHR2 | ALDH1A1 438/4885KMT2A 2155/4885L3MBTL1 1462/4885 |
| US-20110003759-A1 | NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS AND METHODS | MCHR1, MCHR2, MC1R | ALDH1A1 733/4885KMT2A 1379/4885L3MBTL1 937/4885 |
| US-20090011994-A1 | NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS AND METHODS | MCHR1, MCHR2, MC1R | ALDH1A1 733/4885KMT2A 1379/4885L3MBTL1 937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.