Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.68 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.57 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.57 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.53 |
| ▸ | VDR | P11473 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.51 |
| ▸ | BAD | Q92934 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12149695 | 0.94 | FDPS (0.68) | FDPSPARP10PARP15PTGER4MCL1 | |
| SCHEMBL12149861 | 0.91 | PARP10 (0.67) | FDPSPARP10PARP15MCL1KEAP1 | |
| SCHEMBL1378315 | 0.90 | FDPS (0.78) | FDPSPARP10PARP15PTGER4MCL1 | |
| SCHEMBL12149587 | 0.89 | FDPS (0.70) | FDPSPARP10PARP15PTGER4MCL1 | |
| SCHEMBL12149693 | 0.87 | FDPS (0.70) | FDPSPARP10PARP15MCL1BAD | |
| SCHEMBL12149684 | 0.86 | FDPS (0.70) | FDPSPARP10PARP15PTGER4MCL1 | |
| SCHEMBL12151721 | 0.86 | FDPS (0.62) | FDPSPARP10PARP15PTGER4MCL1 | |
| SCHEMBL1377048 | 0.86 | FDPS (0.66) | FDPSPARP10PARP15PTGER4MCL1 | |
| SCHEMBL12149856 | 0.85 | PARP10 (0.60) | FDPSPARP10PARP15MCL1KEAP1 | |
| SCHEMBL12149699 | 0.85 | FDPS (0.74) | FDPSPARP10PARP15PTGER4MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110288057-A1 | SALICYLIC ACID DERIVATIVES BEING FARNESYL PYROPHOSPHATE SYNTHASE ACTIVITY INHIBITORS | NOVARTIS AG (CH) | 2011-11-24 | — | — | US | disclosed |
| US-20110288057-A1 | SALICYLIC ACID DERIVATIVES BEING FARNESYL PYROPHOSPHATE SYNTHASE ACTIVITY INHIBITORS | NOVARTIS AG (CH) | 2011-11-24 | — | — | US | disclosed |
| WO-2010043584-A1 | SALICYLIC ACID DERIVATIVES BEING FARNESYL PYROPHOSPHATE SYNTHASE ACTIVITY INHIBITORS | NOVARTIS AG (CH) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288057-A1 | SALICYLIC ACID DERIVATIVES BEING FARNESYL PYROPHOSPHATE SYNTHASE ACTIVITY INHIBITORS | FDPS, GGPS1, COASY | FDPS 1/4885PARP10 1018/4885PARP15 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.