Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ACACB | O00763 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | LCAT | P04180 | 1/20 | 0.33 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1734816 | 0.79 | KDM4E (0.60) | KDM4ELMNAABL1HRH3KMT2A | |
| SCHEMBL2617748 | 0.71 | PLD1 (0.49) | KDM4EHRH3KMT2ACYP3A4GPR119 | |
| Hydrochloric Acid SCHEMBL2119097 | 0.70 | PLD1 (0.47) | KDM4EHRH3KMT2ACYP3A4GPR119 | |
| SCHEMBL17538374 | 0.69 | KDM4E (0.57) | KDM4ELMNAABL1HRH3KMT2A | |
| SCHEMBL15247289 | 0.67 | LCAT (0.46) | LMNAHRH3MAPTACACBTP53 | |
| SCHEMBL2122299 | 0.67 | GPR119 (0.54) | LMNAKMT2AMAPTGPR119SMN1; SMN2 | |
| SCHEMBL30893593 | 0.67 | GPR119 (0.54) | LMNAKMT2AMAPTGPR119SMN1; SMN2 | |
| SCHEMBL18350234 | 0.66 | DPP4 (0.35) | KDM4ELMNAABL1HRH3MAPT | |
| SCHEMBL10141652 | 0.66 | LCAT (0.47) | HRH3MAPTACACBGPR119LCAT | |
| SCHEMBL13012217 | 0.65 | KDM4E (0.44) | KDM4EHRH3KMT2AGPR119SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954287-B1 | CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2011-11-16 | — | — | EP | disclosed |