Phenmetrazine

Phenmetrazine

SCHEMBL121536

CC1NCCOC1c1ccccc1.Cl

nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC6A2SLC6A3

The experimentally established mechanism targets of Phenmetrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 5/20 0.96
SLC6A3 known ✓ Q01959 5/20 0.96
ADRA1A P35348 1/20 0.96
HTR2B P41595 1/20 0.96
CHRNA7 P36544 1/20 0.70
HTR1A P08908 1/20 0.50
CYP2C19 P33261 2/20 0.46
CYP2D6 P10635 4/20 0.41
SLC6A4 P31645 4/20 0.41
KCNH2 Q12809 2/20 0.41
TSHR P16473 1/20 0.38
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
TACR1 P25103 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
GAA P10253 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenmetrazine SCHEMBL33984 0.98 SLC6A2 (1.00) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL15159761 0.98 SLC6A2 (1.00) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL8094204 0.98 SLC6A2 (1.00) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL15159760 0.98 SLC6A2 (1.00) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL15154744 0.98 SLC6A2 (1.00) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL265002 0.98 SLC6A2 (1.00) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL22462307 0.96 SLC6A2 (0.96) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL3341647 0.89 SLC6A2 (0.81) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
SCHEMBL1666720 0.87 SLC6A2 (0.80) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL28570473 0.85 SLC6A2 (0.74) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3902 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220170019-A1 NANOSYSTEM BASED ON MICRORNA FOR TREATING OBSESITY UNIVERSIDAD DE MÁLAGA (ES) 2022-06-02 US claimed
EP-3960859-A1 NANOSYSTEM BASED ON MICRORNA FOR TREATING OBSESITY Servicio Andaluz De Salud (ES) 2022-03-02 EP claimed
CN-114053206-A Medicinal floating preparation and preparation method thereof 常州恒邦药业有限公司 2022-02-18 CN claimed
CN-114053207-A Sustained-release pharmaceutical composition and preparation method thereof 常州恒邦药业有限公司 2022-02-18 CN claimed
US-20220008334-A1 GASTRIC RETENTIVE DEVICES CLEXIO BIOSCIENCES LTD. (IL) 2022-01-13 US claimed
US-11147766-B2 Gastric retentive devices CLEXIO BIOSCIENCES LTD. (IL) 2021-10-19 US claimed
WO-2020165482-A1 NANOSYSTEM BASED ON MICRORNA FOR TREATING OBSESITY SERVICIO ANDALUZ DE SALUD (ES) 2020-08-20 WO claimed
US-9649093-B2 Cavity-filling biopsy site markers SENORX, INC. (US) 2017-05-16 US claimed
US-20160120510-A1 CAVITY-FILLING BIOPSY SITE MARKERS SENORX, INC. 2016-05-05 US claimed
US-8679535-B2 Sustained release matrix systems for highly soluble drugs ENDO PHARMACEUTICALS INC. (US) 2014-03-25 US claimed
WO-2003089012-A2 CAVITY FILLING BIOPSY SITE MARKER SENORX, INC. (US) 2003-10-30 WO claimed
US-20020188196-A1 Cavity-filling biopsy site markers SENORX, INC. 2002-12-12 US claimed
US-20020044968-A1 High amount of plasticizer to facilitate plasticization of the matrix material at low shear and then reduced prior to adding the encapsulant to reduce post extrusion GENERAL MILLS, INC. 2002-04-18 US claimed
JP-2002511777-A 2002-04-16 JP claimed
EP-1119345-A1 ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES GENERAL MILLS, INC. (US) 2001-08-01 EP claimed
WO-2000021504-A1 ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES GENERAL MILLS, INC. (US) 2000-04-20 WO claimed
EP-0935523-A4 EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES GEN MILLS INC (US) 1999-12-29 EP claimed
EP-0935523-A1 EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES GENERAL MILLS, INC. (US) 1999-08-18 EP claimed
WO-1998018610-A1 EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES LENGERICH BERNHARD H VAN (US) 1998-05-07 WO claimed
US-5023088-A Drug delivery dispenser ALZA CORPORATION (US) 1991-06-11 US claimed