Phenmetrazine

Phenmetrazine

SCHEMBL3341647

CC1NCCOC1c1ccccc1.O=S(=O)(O)O

nearest known ligand 0.81

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC6A2SLC6A3

The experimentally established mechanism targets of Phenmetrazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC6A2 known ✓ P23975 6/20 0.81
SLC6A3 known ✓ Q01959 5/20 0.81
ADRA1A P35348 1/20 0.81
HTR2B P41595 1/20 0.81
CHRNA7 P36544 1/20 0.60
HTR1A P08908 1/20 0.44
CYP2C19 P33261 2/20 0.41
KDM4E B2RXH2 1/20 0.40
MAPT P10636 1/20 0.40
HPGD P15428 1/20 0.40
CYP2D6 P10635 4/20 0.37
SLC6A4 P31645 4/20 0.37
KCNH2 Q12809 2/20 0.37
TACR1 P25103 4/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenmetrazine SCHEMBL15154744 0.90 SLC6A2 (1.00) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL265002 0.90 SLC6A2 (1.00) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL15159760 0.90 SLC6A2 (1.00) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL33984 0.90 SLC6A2 (1.00) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL15159761 0.90 SLC6A2 (1.00) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL8094204 0.90 SLC6A2 (1.00) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL22462307 0.89 SLC6A2 (0.96) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL121536 0.89 SLC6A2 (0.96) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL28570473 0.84 SLC6A2 (0.74) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7
Phenmetrazine SCHEMBL4392164 0.82 SLC6A2 (0.72) SLC6A2SLC6A3ADRA1AHTR2BCHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010080449-A1 BLOW-MOLDED THIN-WALLED DRUG DELIVERY CAPSULES ADDS PHARMACEUTICALS LLC (US) 2010-07-15 WO disclosed
US-20100158997-A1 BLOW-MOLDED THIN-WALLED DRUG DELIVERY CAPSULES ADDS PHARMACEUTICALS LLC 2010-06-24 US disclosed
US-6719751-B2 Osmotic dosage form composed of an extruded polymer tube form DURECT CORPORATION 2004-04-13 US disclosed
EP-1057478-B1 Thermoplastic polymer membranes ALZA CORP (US) 2003-07-09 EP disclosed
US-20030055408-A1 Osmotic dosage form composed of an extruded polymer tube form DURECT CORPORATION 2003-03-20 US disclosed
US-6491683-B1 Osmotic dosage form composed of an extruded polymer tube form ALZA CORPORATION 2002-12-10 US disclosed
EP-0782440-B1 INJECTION-MOLDED DOSAGE FORM ALZA CORP (US) 2001-07-25 EP disclosed
EP-1057478-A2 Thermoplastic polymer membranes ALZA CORPORATION (US) 2000-12-06 EP disclosed
US-6153678-A Injection-moldable composition and article of manufacture comprising same ALZA CORPORATION (US) 2000-11-28 US disclosed
WO-1999018159-A1 INJECTION-MOLDABLE COMPOSITION AND ARTICLE OF MANUFACTURE COMPRISING SAME ALZA CORPORATION (US) 1999-04-15 WO disclosed
US-5830502-A SOLVENT-FREE HOUSING ALZA CORPORATION (US) 1998-11-03 US disclosed
EP-0782440-A1 INJECTION-MOLDED DOSAGE FORM ALZA CORPORATION (US) 1997-07-09 EP disclosed
US-5614578-A Injection-molded dosage form ALZA CORPORATION (US) 1997-03-25 US disclosed
WO-1996013248-A1 INJECTION-MOLDED DOSAGE FORM ALZA CORPORATION (US) 1996-05-09 WO disclosed