Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.53 |
| ▸ | VKORC1 | Q9BQB6 | 2/20 | 0.51 |
| ▸ | SLC26A3 | P40879 | 5/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.44 |
| ▸ | NQO1 | P15559 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12172454 | 0.95 | MAOB (0.49) | MAOBVKORC1SLC26A3MAOABRAF | |
| SCHEMBL12172706 | 0.86 | MAOB (0.54) | MAOBVKORC1SLC26A3MAOAIDO1 | |
| SCHEMBL12155353 | 0.86 | MAOB (0.64) | MAOBVKORC1SLC26A3MAOAAR | |
| SCHEMBL12155359 | 0.85 | VKORC1 (0.67) | MAOBVKORC1MAOAESR1AR | |
| SCHEMBL12155344 | 0.81 | NQO1 (0.61) | MAOBVKORC1ESR1ARHSD17B3 | |
| SCHEMBL12155693 | 0.79 | MAOB (0.55) | MAOBSLC26A3MAOAANO1NR4A2 | |
| SCHEMBL12155361 | 0.74 | VKORC1 (0.51) | MAOBVKORC1HSD17B3NQO1 | |
| SCHEMBL333773 | 0.73 | MAOB (0.47) | MAOBVKORC1MAOAESR1AR | |
| SCHEMBL12172710 | 0.72 | VKORC1 (0.50) | MAOBVKORC1MAOAESR1AR | |
| SCHEMBL25253884 | 0.71 | AR (0.48) | MAOBVKORC1MAOAESR1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048889-B2 | 3,4-disubstituted coumarin and quinolone compounds | XTL BIOPHARMACEUTICALS LTD. (IL) | 2011-11-01 | — | — | US | disclosed |
| US-8048889-B2 | 3,4-disubstituted coumarin and quinolone compounds | XTL BIOPHARMACEUTICALS LTD. (IL) | 2011-11-01 | — | — | US | disclosed |
| WO-2007133211-A1 | 3,4-DISUBSTITUTED COUMARIN AND QUINOLONE COMPOUNDS | XTL BIOPHARMACEUTICALS, LTD. (IL) | 2007-11-22 | — | — | WO | disclosed |