Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | IL2 | P60568 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12241440 | 0.90 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL12155512 | 0.90 | MAPT (0.43) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL12241418 | 0.90 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL12156250 | 0.89 | SMN1; SMN2 (0.47) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL12241433 | 0.89 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL1702038 | 0.87 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL12241419 | 0.86 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL12241435 | 0.85 | RAB9A (0.47) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL12241425 | 0.85 | PDCD1 (0.47) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL12241426 | 0.85 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563776-B1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC (US) | 2016-06-08 | — | — | EP | disclosed |
| US-9120751-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2015-09-01 | — | — | US | disclosed |
| US-9120751-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2015-09-01 | — | — | US | disclosed |
| US-8980629-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2015-03-17 | — | — | US | disclosed |
| WO-2011139489-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-11-10 | — | — | WO | disclosed |