Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 4/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.44 |
| ▸ | ABL1 | P00519 | 13/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12155909 | 1.00 | STIM1 (0.44) | STIM1ORAI1ABL1GPR55NPC1 | |
| SCHEMBL12241630 | 0.88 | ABL1 (0.47) | STIM1ORAI1ABL1NPC1MAPT | |
| SCHEMBL12241637 | 0.88 | ABL1 (0.47) | STIM1ORAI1ABL1NPC1MAPT | |
| SCHEMBL17805360 | 0.82 | STIM1 (0.46) | STIM1ORAI1ABL1 | |
| SCHEMBL16572608 | 0.79 | STIM1 (0.46) | STIM1ORAI1ABL1NPC1RAB9A | |
| SCHEMBL12241621 | 0.79 | IL2 (0.54) | STIM1ORAI1ABL1NPC1RAB9A | |
| SCHEMBL12241618 | 0.79 | IL2 (0.54) | STIM1ORAI1ABL1NPC1RAB9A | |
| SCHEMBL16572602 | 0.79 | STIM1 (0.46) | STIM1ORAI1ABL1NPC1RAB9A | |
| SCHEMBL14225921 | 0.75 | STIM1 (0.78) | STIM1ORAI1 | |
| SCHEMBL14239038 | 0.75 | STIM1 (0.66) | STIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011139489-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-11-10 | — | — | WO | disclosed |