Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 7/20 | 0.46 |
| ▸ | ORAI1 | Q96D31 | 7/20 | 0.46 |
| ▸ | ABL1 | P00519 | 8/20 | 0.34 |
| ▸ | IL2 | P60568 | 3/20 | 0.34 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16572602 | 0.89 | STIM1 (0.46) | STIM1ORAI1ABL1IL2ORAI2 | |
| SCHEMBL16572608 | 0.89 | STIM1 (0.46) | STIM1ORAI1ABL1IL2ORAI2 | |
| SCHEMBL12156163 | 0.86 | STIM1 (0.42) | STIM1ORAI1ABL1IL2 | |
| SCHEMBL12155665 | 0.82 | STIM1 (0.44) | STIM1ORAI1ABL1 | |
| SCHEMBL12155909 | 0.82 | STIM1 (0.44) | STIM1ORAI1ABL1 | |
| SCHEMBL14239038 | 0.82 | STIM1 (0.66) | STIM1ORAI1 | |
| SCHEMBL12241621 | 0.81 | IL2 (0.54) | STIM1ORAI1ABL1IL2ORAI2 | |
| SCHEMBL12241618 | 0.81 | IL2 (0.54) | STIM1ORAI1ABL1IL2ORAI2 | |
| SCHEMBL14239062 | 0.80 | STIM1 (0.66) | STIM1ORAI1ABL1IL2ORAI2 | |
| SCHEMBL12241630 | 0.79 | ABL1 (0.47) | STIM1ORAI1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563776-B1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC (US) | 2016-06-08 | — | — | EP | disclosed |