Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12156362 | 0.94 | S1PR1 (0.42) | S1PR1MMP1MMP2MMP3MMP13 | |
| SCHEMBL12156369 | 0.93 | MMP2 (0.47) | S1PR1MMP1MMP2MMP3MMP13 | |
| SCHEMBL12156381 | 0.93 | S1PR1 (0.51) | S1PR1MMP1MMP2MMP3MMP13 | |
| SCHEMBL12156374 | 0.92 | S1PR1 (0.40) | S1PR1MMP1MMP2MMP3MMP13 | |
| SCHEMBL12156372 | 0.91 | HTR2A (0.43) | S1PR1MMP1MMP2MMP3MMP13 | |
| SCHEMBL12156376 | 0.91 | S1PR1 (0.42) | S1PR1MMP1MMP2MMP3MMP13 | |
| SCHEMBL12156375 | 0.91 | S1PR1 (0.41) | S1PR1MMP1MMP2MMP3MMP13 | |
| SCHEMBL12156385 | 0.91 | POLB (0.44) | S1PR1MMP1MMP2MMP3MMP13 | |
| SCHEMBL12156331 | 0.90 | S1PR1 (0.43) | S1PR1MMP1MMP2MMP3MMP13 | |
| SCHEMBL12156367 | 0.90 | BRD4 (0.41) | S1PR1MMP1MMP2MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048898-B2 | Inhibitor of binding of S1P1 | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2011-11-01 | — | — | US | disclosed |
| US-8048898-B2 | Inhibitor of binding of S1P1 | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2011-11-01 | — | — | US | disclosed |
| US-20100234594-A1 | INHIBITOR OF BINDING OF S1P1 | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2010-09-16 | — | — | US | disclosed |
| US-20100234594-A1 | INHIBITOR OF BINDING OF S1P1 | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234594-A1 | INHIBITOR OF BINDING OF S1P1 | S1PR1, S1PR3, EDNRB | S1PR1 1/4885TP53 738/4885MMP1 1251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.