Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 4/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6056252 | 1.00 | GAA (0.44) | GAAMAPTCREBBPBRPF1NOS2 | |
| SCHEMBL4705187 | 0.77 | CREBBP (0.38) | GAAMAPTCREBBPBRPF1NOS2 | |
| SCHEMBL24383177 | 0.75 | NOS2 (0.39) | GAAMAPTCREBBPBRPF1NOS2 | |
| SCHEMBL4283708 | 0.74 | GAA (0.44) | GAAMAPTCREBBPBRPF1BRD4 | |
| SCHEMBL5470066 | 0.74 | GAA (0.44) | GAAMAPTNOS2 | |
| SCHEMBL7442660 | 0.74 | GAA (0.44) | GAAMAPTMEN1KMT2AALOX15 | |
| SCHEMBL6111309 | 0.74 | GAA (0.44) | GAAMAPTCREBBPBRD4P2RX4 | |
| SCHEMBL18562457 | 0.74 | GAA (0.44) | GAAMAPT | |
| SCHEMBL4540870 | 0.74 | GAA (0.44) | GAAMAPT | |
| SCHEMBL13368086 | 0.74 | GAA (0.40) | GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2386553-A1 | BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND THEIR USES | Shanghai Jiao Tong University (CN) | 2011-11-16 | — | — | EP | disclosed |