Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 2/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306271 | 0.89 | POLB (0.37) | TRPM8MAPTTSHRALDH1A1LMNA | |
| SCHEMBL12161510 | 0.81 | ESR1 (0.48) | ESR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL307533 | 0.80 | POLB (0.35) | TRPM8MAPTTSHRALDH1A1LMNA | |
| SCHEMBL10305632 | 0.77 | POLB (0.37) | TRPM8MAPTALDH1A1CCR2 | |
| SCHEMBL12347431 | 0.76 | POLB (0.35) | TRPM8MAPTALDH1A1CCR2SLC6A9 | |
| SCHEMBL306049 | 0.76 | TSHR (0.51) | TSHRCCR2 | |
| SCHEMBL304523 | 0.76 | POLB (0.37) | TRPM8MAPTTSHRALDH1A1LMNA | |
| SCHEMBL306944 | 0.75 | POLB (0.34) | TRPM8MAPTCCR2 | |
| SCHEMBL305479 | 0.74 | TRPM8 (0.38) | TRPM8MAPTTSHRALDH1A1LMNA | |
| SCHEMBL10192356 | 0.73 | TSHR (0.41) | TSHRALDH1A1LMNACCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838674-B9 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX INC (US) | 2011-11-02 | — | — | EP | disclosed |
| EP-1838674-B1 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX INC (US) | 2011-03-30 | — | — | EP | disclosed |