Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 12/20 | 0.51 |
| ▸ | MTOR | P42345 | 9/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL189813 | 0.85 | PIK3CA (0.49) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL13298749 | 0.84 | PIK3CA (0.48) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL13059936 | 0.84 | PIK3CA (0.50) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL17834706 | 0.75 | PIK3CA (0.41) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL29959326 | 0.75 | PIK3CA (0.41) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL25392299 | 0.74 | ALDH3A1 (0.45) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL26079024 | 0.73 | PIK3CA (0.50) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL2674625 | 0.73 | PIK3CD (0.62) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL31290054 | 0.72 | PIK3CA (0.60) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL2673903 | 0.72 | PIK3CA (0.49) | PIK3CAPIK3R1MTORPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041139-B1 | PHARMACEUTICAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2011-11-09 | — | — | EP | disclosed |