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Sugi Predict / Targets / ALDH3A1

ALDH3A1

Aldehyde dehydrogenase, dimeric NADP-preferring · P30838 · ALDH3A1 on Sugi Atlas →

23,262 patent compounds predicted against ALDH3A1, 14,009 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL112129 SCHEMBL112129 0.50 8/20
SCHEMBL456694 SCHEMBL456694 0.50 8/20
SCHEMBL281757 SCHEMBL281757 0.46 8/20
SCHEMBL490223 SCHEMBL490223 0.44 8/20
SCHEMBL490225 SCHEMBL490225 0.44 8/20
SCHEMBL578265 SCHEMBL578265 0.71 7/20
SCHEMBL685083 SCHEMBL685083 0.43 7/20
SCHEMBL281511 SCHEMBL281511 0.67 6/20
SCHEMBL281461 SCHEMBL281461 0.58 6/20
SCHEMBL608504 SCHEMBL608504 0.54 6/20
SCHEMBL608505 SCHEMBL608505 0.54 6/20
SCHEMBL281661 SCHEMBL281661 0.48 6/20
SCHEMBL433470 SCHEMBL433470 0.46 6/20
SCHEMBL281618 SCHEMBL281618 0.71 5/20
SCHEMBL571882 SCHEMBL571882 0.68 5/20
SCHEMBL281897 SCHEMBL281897 0.68 5/20
SCHEMBL281962 SCHEMBL281962 0.64 5/20
SCHEMBL281270 SCHEMBL281270 0.62 5/20
SCHEMBL578329 SCHEMBL578329 0.62 5/20
SCHEMBL950088 SCHEMBL950088 0.62 5/20

Clinical trials — most relevant to ALDH3A1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Disulfiram and Cisplatin in Refractory TGCTs. PHASE2COMPLETED
Carboplatin and Eribulin Mesylate in Triple Negative Breast Cancer Patients PHASE2UNKNOWN
Evaluation of Psilocybin-Assisted Psychotherapy in Treating Severe Depression in Patients With PTSD PHASE2UNKNOWN
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy PHASE2ACTIVE_NOT_RECRUITING
Non-oxidative Metabolite Profiles After Increasing Doses of Ethanol PHASE1COMPLETED
Fetal Umbilical Cord Blood (UCB) Transplant for Lysosomal Storage Diseases PHASE1WITHDRAWN
ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients nanRECRUITING
ALDH2 Genetic Testing in East Asian Community nanNOT_YET_RECRUITING
Public Health Initiative on Alcohol Flushing nanCOMPLETED
Functional Investigation of Endothelial Function and Regenerative Cell Exhaustion nanNOT_YET_RECRUITING
Bipolar Disorder With Alcoholism in Han Chinese nanUNKNOWN
Environmental and Biological Monitoring Pilot Study for Polycyclic Aromatic Hydrocarbons in Linxian, China nanCOMPLETED
Alcohol Metabolism and Disease Risk in Asians nanCOMPLETED
ADH1B and ALDH Gene Variants and Lung Cancer Risk nanNOT_YET_RECRUITING
Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC nanCOMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside nanUNKNOWN
Determination of ALDH1b1 and ALDH2 Polymorphisms Frequency in the Brazilian Population nanUNKNOWN
Study of Protein Translocation in Patients With Beta-Oxidation Disorders nanCOMPLETED
Adrenoleukodystrophy National Registry Study nanRECRUITING
Pharmacogenetic Determinants Of Treatment Response In Children nanRECRUITING
Genetic Polymorphisms in UGT1A6 and UGT2B7 in Asian Population: Association With Lung Cancer Phenotype nanUNKNOWN
Relationship Between ALDH2 and CIN nanUNKNOWN
Genetic and Environmental Risk Factors Related to Esophageal Cancer nanACTIVE_NOT_RECRUITING
Pharmacogenetic and Neurofunctional Brain Areas Study in Obese Patients With Binge Eating Disorder nanUNKNOWN
Cancer and Hearing Loss Related in Children nanCOMPLETED
The Genetic Basis for Vulnerability to Substance Abuse nanCOMPLETED
Tamoxifen Pharmacogenetics in Asian Breast Cancer Women nanUNKNOWN
Fatty Acid Oxidation Defects and Insulin Sensitivity nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a ALDH3A1 binder may also engage these)

ProteinNameSimilarity
P11883 — 0.997 P11883 →
A3RF36 — 0.995 A3RF36 →
P47740 — 0.993 P47740 →
P47739 — 0.991 P47739 →
Q5RF60 — 0.988 Q5RF60 →
P51648 — 0.988 P51648 →
P30839 — 0.988 P30839 →
J3QMK6 — 0.988 J3QMK6 →
Q60HH8 — 0.988 Q60HH8 →
Q5XI42 — 0.987 Q5XI42 →
Q80VQ0 — 0.986 Q80VQ0 →
E9Q3E1 — 0.985 E9Q3E1 →
Q54DG1 — 0.984 Q54DG1 →
Q8VXQ2 — 0.984 Q8VXQ2 →
Q84DC3 — 0.982 Q84DC3 →
A6VZ85 — 0.981 A6VZ85 →
P81178 — 0.981 P81178 →
Q70E96 — 0.980 Q70E96 →
Q2XQV4 — 0.980 Q2XQV4 →
Q19A30 — 0.979 Q19A30 →
Q70DU8 — 0.979 Q70DU8 →
P51977 — 0.979 P51977 →
ALDH1B1 Aldehyde dehydrogenase X, mitochondrial 0.979 landscape →
P13601 — 0.979 P13601 →
P39616 — 0.979 P39616 →
ALDH1A1 Aldehyde dehydrogenase 1A1 0.979 landscape →
P48644 — 0.979 P48644 →
Q8HYE4 — 0.978 Q8HYE4 →
P12693 — 0.978 P12693 →
Q83R90 — 0.978 Q83R90 →