Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL190607 | 0.80 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CBPIK3R1PIK3CG | |
| SCHEMBL12166214 | 0.76 | PIK3CA (0.56) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL190336 | 0.71 | PIK3CD (0.86) | PIK3CDPIK3CAPIK3CBPIK3R1PIK3CG | |
| SCHEMBL12166291 | 0.67 | PIK3CA (0.54) | PIK3CDPIK3CAPIK3CBPIK3R1PIK3CG | |
| SCHEMBL12166180 | 0.67 | PIK3CA (0.69) | PIK3CDPIK3CAPIK3CBPIK3R1PIK3CG | |
| SCHEMBL12166394 | 0.66 | PIK3CA (0.55) | PIK3CDKDM4EALOX15PIK3CAPIK3CB | |
| SCHEMBL12166377 | 0.66 | ABCC4 (0.48) | PIK3CDPIK3CAPIK3CBPIK3R1PIK3CG | |
| SCHEMBL12166371 | 0.65 | PIK3CA (0.56) | PIK3CDPIK3CAPIK3CBPIK3R1PIK3CG | |
| SCHEMBL11197951 | 0.64 | KDM4E (0.50) | KDM4EALOX15 | |
| SCHEMBL190138 | 0.63 | PIK3CA (0.75) | PIK3CDPIK3CAPIK3CBPIK3R1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041139-B1 | PHARMACEUTICAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2011-11-09 | — | — | EP | disclosed |