Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 16/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12166298 | 0.91 | PIK3CA (0.46) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166269 | 0.88 | PIK3CA (0.47) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL191037 | 0.82 | PIK3CA (0.74) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166366 | 0.81 | PIK3CA (0.58) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL23634757 | 0.79 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1620360 | 0.78 | HDAC3 (0.45) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166278 | 0.77 | ABCC4 (0.54) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166265 | 0.77 | PIK3CD (0.56) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166258 | 0.77 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166246 | 0.76 | PIK3CD (0.57) | PIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041139-B1 | PHARMACEUTICAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2011-11-09 | — | — | EP | disclosed |