Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 18/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 17/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 17/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL190835 | 0.88 | PIK3CA (0.69) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166375 | 0.82 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL191037 | 0.78 | PIK3CA (0.74) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166267 | 0.77 | PIK3CD (0.61) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1088290 | 0.77 | PIK3CD (0.77) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166255 | 0.77 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1088308 | 0.76 | PIK3CD (0.76) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL189436 | 0.75 | PIK3CA (0.69) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL190690 | 0.74 | PIK3CA (0.67) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL1088332 | 0.74 | PIK3CA (0.84) | PIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041139-B1 | PHARMACEUTICAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2011-11-09 | — | — | EP | disclosed |