Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.55 |
| ▸ | PARP1 | P09874 | 3/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.53 |
| ▸ | MTOR | P42345 | 8/20 | 0.53 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.53 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.53 |
| ▸ | STK10 | O94804 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | FGR | P09769 | 1/20 | 0.53 |
| ▸ | FER | P16591 | 1/20 | 0.53 |
| ▸ | PRKCA | P17252 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TEC | P42680 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | PRKDC | P78527 | 1/20 | 0.53 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191468 | 0.87 | PIK3CA (0.70) | PIK3CAPARP1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL191469 | 0.87 | PIK3CA (0.70) | PIK3CAPARP1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166300 | 0.73 | PIK3CA (0.42) | PIK3CAPARP1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL190025 | 0.73 | PIK3CA (0.76) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL189847 | 0.73 | PIK3CA (0.76) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL190325 | 0.73 | PIK3CA (0.76) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL12166271 | 0.72 | PIK3CD (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL190192 | 0.72 | PIK3CA (0.73) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL190191 | 0.72 | PIK3CA (0.73) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL190537 | 0.72 | PIK3CA (0.73) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041139-B1 | PHARMACEUTICAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2011-11-09 | — | — | EP | disclosed |