Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL189647 | 0.86 | PIK3CA (0.57) | PIK3CAPARP1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166258 | 0.74 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166296 | 0.73 | PIK3CA (0.55) | PIK3CAPARP1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL191037 | 0.72 | PIK3CA (0.74) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL190349 | 0.71 | PIK3CA (0.62) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL12166255 | 0.71 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166375 | 0.71 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1859402 | 0.69 | PIK3CA (0.65) | PIK3CAPARP1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL1860734 | 0.69 | PIK3CA (0.58) | PIK3CAPARP1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL19142913 | 0.69 | PIK3CA (0.56) | PIK3CAPARP1PIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041139-B1 | PHARMACEUTICAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2011-11-09 | — | — | EP | disclosed |