Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 7/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.59 |
| ▸ | RECQL | P46063 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12177564 | 0.96 | PSMB8 (0.67) | PSMB8ALDH1A1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL12177176 | 0.93 | PSMB8 (0.71) | PSMB8ALDH1A1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL12177333 | 0.91 | PSMB8 (0.62) | PSMB8ALDH1A1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL12177213 | 0.91 | PSMB8 (0.75) | PSMB8ALDH1A1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL12177546 | 0.89 | PSMB8 (0.57) | PSMB8ALDH1A1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL12177429 | 0.88 | PSMB8 (0.65) | PSMB8ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL12177187 | 0.88 | PSMB8 (0.80) | PSMB8ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL12177746 | 0.88 | PSMB8 (0.73) | PSMB8ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL12177594 | 0.83 | PSMB8 (0.70) | PSMB8ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL12177782 | 0.81 | PSMB8 (0.82) | PSMB8ALDH1A1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011135303-A2 | UBIQUITINATION MODULATORS | ITI SCOTLAND LIMITED (GB) | 2011-11-03 | — | — | WO | disclosed |