Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 7/20 | 0.71 |
| ▸ | INSR | P06213 | 6/20 | 0.71 |
| ▸ | IGF1R | P08069 | 6/20 | 0.71 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.68 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.66 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.66 |
| ▸ | CDC7 | O00311 | 3/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.60 |
| ▸ | JAK2 | O60674 | 3/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.60 |
| ▸ | PAK4 | O96013 | 3/20 | 0.60 |
| ▸ | CDK2 | P24941 | 3/20 | 0.60 |
| ▸ | CLK2 | P49760 | 3/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.60 |
| ▸ | MELK | Q14680 | 3/20 | 0.60 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.60 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.60 |
| ▸ | PLK4 | O00444 | 2/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2589418 | 0.90 | ZAP70 (0.67) | ALKINSRIGF1RZAP70MAPK9 | |
| SCHEMBL30631286 | 0.90 | ZAP70 (0.67) | ALKINSRIGF1RZAP70MAPK9 | |
| SCHEMBL2594892 | 0.84 | ULK1 (0.65) | ALKINSRIGF1RZAP70MAPK9 | |
| SCHEMBL11916506 | 0.83 | ALK (1.00) | ALKINSRIGF1RZAP70MAPK9 | |
| SCHEMBL13832205 | 0.78 | ALK (0.67) | ALKINSRIGF1RZAP70 | |
| SCHEMBL2595609 | 0.78 | ALK (0.71) | ALKINSRIGF1RZAP70MAPK9 | |
| SCHEMBL30631285 | 0.78 | ALK (0.71) | ALKINSRIGF1RZAP70MAPK9 | |
| Hydrochloric Acid SCHEMBL2592568 | 0.77 | ALK (0.70) | ALKINSRIGF1RZAP70MAPK9 | |
| SCHEMBL14982993 | 0.77 | ULK1 (0.67) | ALKINSRIGF1RMAPK9MAPK10 | |
| SCHEMBL17792883 | 0.76 | ZAP70 (0.57) | ALKINSRIGF1RZAP70MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011140338-A1 | COMPOUNDS THAT MODULATE EGFR ACTIVITY AND METHODS FOR TREATING OR PREVENTING CONDITIONS THEREWITH | Gatekeeper Pharmaceuticals, Inc. (US) | 2011-11-10 | — | — | WO | disclosed |