SCHEMBL12180263

SCHEMBL12180263

OCCn1ccc2c(-n3c(-c4ccc(O)cc4O)n[nH]c3=S)cccc21

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 5/20 0.48
HSP90AB1 P08238 1/20 0.48
KDM4E B2RXH2 4/20 0.47
MAPT P10636 2/20 0.47
GAA P10253 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
ALDH1A1 P00352 5/20 0.45
HPGD P15428 5/20 0.45
LMNA P02545 1/20 0.45
STAT3 P40763 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
HTR6 P50406 4/20 0.36
ALOX15 P16050 1/20 0.36
HSD17B10 Q99714 1/20 0.36
POLB P06746 1/20 0.35
GFER P55789 1/20 0.34
TSHR P16473 1/20 0.34
APOBEC3G Q9HC16 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10072746 0.92 HSP90AA1 (0.44) HSP90AA1HSP90AB1KDM4EMAPTGAA
SCHEMBL421083 0.89 HSP90AA1 (0.51) HSP90AA1HSP90AB1KDM4EMAPTGAA
SCHEMBL419759 0.89 HSP90AA1 (0.58) HSP90AA1HSP90AB1KDM4EMAPTGAA
SCHEMBL12066695 0.82 HSP90AA1 (0.46) HSP90AA1HSP90AB1KDM4EMAPTGAA
SCHEMBL12285611 0.82 HSP90AA1 (0.53) HSP90AA1HSP90AB1KDM4EMAPTGAA
SCHEMBL420040 0.81 KDM4E (0.50) HSP90AA1HSP90AB1KDM4EMAPTGAA
SCHEMBL12180117 0.78 HSP90AA1 (0.56) HSP90AA1HSP90AB1KDM4EMAPTGAA
SCHEMBL420101 0.78 HSP90AA1 (0.42) HSP90AA1HSP90AB1KDM4EMAPTGAA
SCHEMBL419793 0.78 KDM4E (0.47) HSP90AA1HSP90AB1KDM4EMAPTGAA
SCHEMBL9924878 0.78 KDM4E (0.47) HSP90AA1HSP90AB1KDM4EMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012116247-A1 HSP90 INHIBITORY COMPOUNDS IN TREATING JAK/STAT SIGNALING-MEDIATED CANCERS SYNTA PHARMACEUTICALS CORP. (US) 2012-08-30 WO disclosed
WO-2011146801-A1 FORMULATION AND DOSING OF HSP90 INHIBITORY COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2011-11-24 WO disclosed