Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10072747 | 0.94 | HSP90AA1 (0.41) | KDM4EMAPTGAAL3MBTL1HSP90AA1 | |
| SCHEMBL419793 | 0.87 | KDM4E (0.47) | KDM4EMAPTGAAL3MBTL1HSP90AA1 | |
| SCHEMBL421083 | 0.81 | HSP90AA1 (0.51) | KDM4EMAPTGAAL3MBTL1HSP90AA1 | |
| SCHEMBL420040 | 0.81 | KDM4E (0.50) | KDM4EMAPTGAAL3MBTL1HSP90AA1 | |
| SCHEMBL14136222 | 0.80 | HSP90AA1 (0.41) | KDM4EMAPTGAAL3MBTL1HSP90AA1 | |
| SCHEMBL12180263 | 0.78 | HSP90AA1 (0.48) | KDM4EMAPTGAAL3MBTL1HSP90AA1 | |
| SCHEMBL419759 | 0.77 | HSP90AA1 (0.58) | KDM4EMAPTGAAL3MBTL1HSP90AA1 | |
| SCHEMBL15868432 | 0.76 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1 | |
| SCHEMBL12180117 | 0.76 | HSP90AA1 (0.56) | KDM4EMAPTGAAL3MBTL1HSP90AA1 | |
| SCHEMBL12180084 | 0.76 | HSP90AA1 (0.50) | KDM4EMAPTGAAL3MBTL1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078757-A2 | COMBINATION BREAST CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011146801-A1 | FORMULATION AND DOSING OF HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2011-11-24 | — | — | WO | disclosed |
| WO-2011049946-A1 | COMBINATION CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2011-04-28 | — | — | WO | disclosed |
| WO-2007140002-A2 | METHOD FOR TREATING NON-HODGKIN'S LYMPHOMA | SYNTA PHARMACEUTICALS CORP. (US) | 2007-12-06 | — | — | WO | disclosed |