Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 5/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14749309 | 0.94 | PRCP (0.49) | PRCPNR1H2SMN1; SMN2MAPT | |
| SCHEMBL14749290 | 0.88 | PRCP (0.47) | PRCPDPP4NR1H2SMN1; SMN2TDP1 | |
| SCHEMBL14736703 | 0.82 | PRCP (0.55) | PRCPSMN1; SMN2LMNAPOLBMAPT | |
| SCHEMBL12183894 | 0.81 | PRCP (0.51) | PRCPNR1H2LMNATP53GPR119 | |
| SCHEMBL14749311 | 0.79 | PRCP (0.49) | PRCPNR1H2LMNATP53GPR119 | |
| SCHEMBL12183915 | 0.75 | PRCP (0.43) | PRCPNR1H2SMN1; SMN2LMNAPOLB | |
| SCHEMBL14749293 | 0.75 | PRCP (0.49) | PRCPSMN1; SMN2TDP1LMNAPOLB | |
| SCHEMBL2597820 | 0.72 | KLK7 (0.41) | NR1H2SMN1; SMN2KLK7 | |
| SCHEMBL2597852 | 0.71 | KLK7 (0.41) | NR1H2SMN1; SMN2MEN1KMT2AKLK7 | |
| SCHEMBL14749302 | 0.69 | PRCP (0.48) | PRCPSMN1; SMN2LMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146354-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-11-24 | — | — | WO | disclosed |