Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 8/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CACNB4 | O00305 | 3/20 | 0.38 |
| ▸ | CACNA1A | O00555 | 3/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.38 |
| ▸ | CACNG3 | O60359 | 3/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.38 |
| ▸ | CACNB3 | P54284 | 3/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.38 |
| ▸ | CACNG7 | P62955 | 3/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 3/20 | 0.38 |
| ▸ | CACNG1 | Q06432 | 3/20 | 0.38 |
| ▸ | CACNB2 | Q08289 | 3/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12183915 | 0.93 | PRCP (0.43) | PRCPTP53LMNAMAPTSMN1; SMN2 | |
| SCHEMBL12184583 | 0.92 | PRCP (0.52) | PRCPLMNA | |
| SCHEMBL12184748 | 0.91 | PRCP (0.50) | PRCPMAPTSMN1; SMN2POLB | |
| SCHEMBL14737070 | 0.88 | PRCP (0.54) | PRCPMAPTSMN1; SMN2POLB | |
| SCHEMBL14749284 | 0.83 | PRCP (0.49) | PRCPTP53LMNAMAPTSMN1; SMN2 | |
| SCHEMBL14752639 | 0.83 | PRCP (0.52) | PRCPMAPTSMN1; SMN2POLB | |
| SCHEMBL14749314 | 0.83 | PRCP (0.58) | PRCPLMNA | |
| SCHEMBL12183916 | 0.83 | PRCP (0.58) | PRCPLMNA | |
| SCHEMBL2599440 | 0.81 | PRCP (0.55) | PRCPLMNACACNB4CACNA1ACACNA1G | |
| SCHEMBL14749421 | 0.81 | PRCP (0.55) | PRCPMAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130059830-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP | 2013-03-07 | — | — | US | disclosed |
| US-20130059830-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP | 2013-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059830-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | PRCP, PREP, ENPEP | PRCP 1/4885KCNK3 4500/4885KCNK9 4030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.