Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 10/20 | 0.46 |
| ▸ | DRD2 | P14416 | 10/20 | 0.46 |
| ▸ | DRD3 | P35462 | 6/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12185574 | 0.89 | PRCP (0.56) | PRCPSIGMAR1DRD4DRD2DRD3 | |
| SCHEMBL14686654 | 0.85 | DRD2 (0.52) | PRCPSIGMAR1DRD4DRD2DRD3 | |
| SCHEMBL12185578 | 0.85 | HTR2A (0.48) | PRCPDRD4DRD2DRD3HTR2A | |
| SCHEMBL12185982 | 0.84 | PRCP (0.68) | PRCPDRD4DRD2DRD3 | |
| SCHEMBL14686445 | 0.82 | PRCP (0.54) | PRCPSIGMAR1DRD4DRD2DRD3 | |
| SCHEMBL12185573 | 0.79 | SMN1; SMN2 (0.48) | PRCPHTR2A | |
| SCHEMBL12186005 | 0.77 | PRCP (0.74) | PRCPDRD4DRD2DRD3ACHE | |
| SCHEMBL14687101 | 0.74 | PRCP (0.67) | PRCPDRD4DRD2DRD3ACHE | |
| SCHEMBL12185551 | 0.72 | PRCP (0.73) | PRCPSIGMAR1DRD4DRD2DRD3 | |
| SCHEMBL14686462 | 0.72 | PRCP (0.84) | PRCPDRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011143057-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-11-17 | — | — | WO | disclosed |