Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 5/20 | 0.89 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CACNB4 | O00305 | 4/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 4/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.39 |
| ▸ | CACNG3 | O60359 | 4/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.39 |
| ▸ | CACNB3 | P54284 | 4/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12186027 | 0.94 | PRCP (1.00) | PRCPSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL14701321 | 0.87 | PRCP (0.86) | PRCPSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL14686665 | 0.81 | PRCP (0.64) | PRCPSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL14688393 | 0.81 | PRCP (0.65) | PRCPSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL12185603 | 0.77 | PRCP (0.60) | PRCPSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2599117 | 0.74 | PRCP (0.56) | PRCPSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL12185619 | 0.72 | PRCP (0.79) | PRCPSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL14686526 | 0.72 | PRCP (0.61) | PRCPSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL14686651 | 0.72 | PRCP (0.76) | PRCPSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL12185531 | 0.69 | PRCP (0.69) | PRCPMEN1KMT2ACYP1A2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2568812-B1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-10-26 | — | — | EP | disclosed |
| EP-2568812-B1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-10-26 | — | — | EP | disclosed |
| US-9365539-B2 | Prolylcarboxypeptidase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-06-14 | — | — | US | disclosed |
| US-9365539-B2 | Prolylcarboxypeptidase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-06-14 | — | — | US | disclosed |
| US-9365539-B2 | Prolylcarboxypeptidase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-06-14 | — | — | US | disclosed |
| US-20130040929-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130040929-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20130040929-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-02-14 | — | — | US | disclosed |
| WO-2011143057-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040929-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | PRCP, PREP, ENPEP | PRCP 1/4885SMN1; SMN2 4754/4885MEN1 3238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.