ENPEP — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL197220	0.40	12/20
Cysteine (SCHEMBL492744)	0.39	12/20
SCHEMBL359384	0.37	12/20
SCHEMBL462748	0.37	12/20
SCHEMBL475492	0.40	11/20
Cysteine (SCHEMBL64115)	0.37	11/20
SCHEMBL456395	0.37	11/20
Cysteine (SCHEMBL663460)	0.37	11/20
Cysteine (SCHEMBL695910)	0.37	11/20
Serine (SCHEMBL418635)	0.39	9/20
SCHEMBL210006	0.48	8/20
SCHEMBL210315	0.48	8/20
SCHEMBL536354	0.48	8/20
Glycine (SCHEMBL343653)	0.44	8/20
SCHEMBL285917	0.35	8/20
SCHEMBL288933	0.59	7/20
SCHEMBL284914	0.52	7/20
SCHEMBL289006	0.52	7/20
SCHEMBL289389	0.50	7/20
SCHEMBL441814	0.50	7/20

Clinical trials — most relevant to ENPEP by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Serum Biomarkers to Predict Response to Angiotensin II in Septic Shock	PHASE4	COMPLETED
Effectiveness of Inactive Vitamin D Supplementation in Non-Alcoholic Fatty Liver Disease Patients	PHASE3	UNKNOWN
Efficacy and Safety of SYR-472 in Subjects With Type 2 Diabetes Mellitus	PHASE2	COMPLETED
Prevention of Cardiac Dysfunction During Breast Cancer Therapy	PHASE2	COMPLETED
Comparative Clinical Study to Evaluate the Possible Efficacy and Safety of Oral N-Acetyl Cysteine Versus Rectal Diclofenac in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis	PHASE1/PHASE2	COMPLETED
Aminopterin Pharmacokinetic Study In Moderate to Severe Psoriasis	PHASE1	COMPLETED
A Clinical Trial to Compare the Safety, Tolerability, and PK Properties of DA-5216 and DA-5216-R and to Evaluate the Food Effect on DA-5216.	PHASE1	UNKNOWN
Protein Digestion and Amino Acid Absorption in the Aging Gastrointestinal Tract	nan	COMPLETED
An Analysis of Urinary Proteases as Biomarkers for Hepatocellular Carcinoma-101423	nan	COMPLETED
Use of Blood Biomarkers for the Early Diagnosis of Hepatocellular Carcinoma (HCC)	nan	UNKNOWN
New Serological Markers for Eosinophilic Esophagitis	nan	UNKNOWN
Neutral Endopeptidase for Early Detection of Acute Kidney Injury After Cardiac Surgery	nan	COMPLETED
Causes, Complications and Outcomes of Severe Acute Liver Disease Cases Admitted to Intensive Care Units	nan	UNKNOWN
Safety Study of Black Cohosh Use by Postmenopausal Women on the Liver	nan	COMPLETED
Natural History of Post-transfusion Non-A, Non-B Hepatitis	nan	COMPLETED
Acute Hepatitis in Pediatrics	nan	RECRUITING
Effect of AN-PEP Enzyme on Gluten Digestion	nan	COMPLETED
DPP4 Activity, Microvascular Reactivity and Inflammation	nan	COMPLETED
Plasma Dipeptidyl-peptidase-4 Activities With No-reflow and Bleeding	nan	COMPLETED
The PORTRAIT Study	nan	UNKNOWN
PSMA Expression and PSMA PET Imaging in Soft Tissue Sarcomas and Urothelial Cell Carcinomas	nan	COMPLETED
Correlation Between PSA Levels and F-18 PSMA PET/CT Findings in Prostate Cancer Patient	nan	RECRUITING
Assessing the Impacts of a UESAD on Laryngeal Symptoms and Salivary Pepsin	nan	COMPLETED
Liver Function Abnormalities in Patients With Acute Heart Failure	nan	NOT_YET_RECRUITING
Influence of External Factors on Skeletal Growth in Youth	nan	ACTIVE_NOT_RECRUITING
A Multicenter Selective Screening Study to Investigate the Frequency of Neuronal Ceroid Lipofuxinosis Type 2 (CLN2)	nan	RECRUITING
Predictive Nomogram of CRPC	nan	UNKNOWN
68Ga-PSMA-617 PET/CT for PSMA-expressing Tumor: a Pragmatic Study	nan	RECRUITING
Haemostatic Imbalance in Patients With Chronic Liver Disease	nan	UNKNOWN
Superior Cervical Ganglion in Parkinson's Disease	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ENPEP binder may also engage these)

Protein	Name	Similarity
A5HUI5	—	1.000	A5HUI5 →
P97449	—	1.000	P97449 →
P15145	—	1.000	P15145 →
Q32LQ0	—	1.000	Q32LQ0 →
ANPEP	Aminopeptidase N	1.000	landscape →
Q95334	—	1.000	Q95334 →
D3UW23	—	1.000	D3UW23 →
P79171	—	1.000	P79171 →
ERAP2	Endoplasmic reticulum aminopeptidase 2	1.000	landscape →
P15541	—	1.000	P15541 →
Q9JJ22	—	0.999	Q9JJ22 →
P50123	—	0.998	P50123 →
O57579	—	0.997	O57579 →
Q9EQH2	—	0.997	Q9EQH2 →
P16406	—	0.996	P16406 →
P79143	—	0.995	P79143 →
P15684	—	0.995	P15684 →
NPEPPS	Puromycin-sensitive aminopeptidase	0.995	landscape →
LNPEP	Leucyl-cystinyl aminopeptidase	0.995	landscape →
Q8C129	—	0.994	Q8C129 →
P97629	—	0.993	P97629 →
P79098	—	0.993	P79098 →
Q6Z6L4	—	0.993	Q6Z6L4 →
Q6K4E7	—	0.993	Q6K4E7 →
ERAP1	Endoplasmic reticulum aminopeptidase 1	0.992	landscape →
Q0J5V5	—	0.992	Q0J5V5 →
Q5RFP3	—	0.992	Q5RFP3 →
A6QPT7	—	0.991	A6QPT7 →
P32454	—	0.991	P32454 →
M3XFH7	—	0.990	M3XFH7 →