⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL595872 | 0.69 | ALDH1A1 (0.44) | — | |
| SCHEMBL10831407 | 0.67 | — | — | |
| SCHEMBL7475263 | 0.65 | — | — | |
| SCHEMBL7486847 | 0.65 | — | — | |
| SCHEMBL1219256 | 0.65 | — | — | |
| SCHEMBL14534318 | 0.65 | — | — | |
| SCHEMBL717817 | 0.65 | — | — | |
| SCHEMBL10873558 | 0.65 | — | — | |
| SCHEMBL5395515 | 0.65 | — | — | |
| SCHEMBL14539704 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0479822-B1 | THERAPEUTIC NUCLEOSIDES | WELLCOME FOUND (GB) | 1999-08-18 | — | — | EP | claimed |
| EP-2292268-A1 | Pharmaceutical composition for use in treatment of diabetes | Takeda Pharmaceutical Company Limited (JP) | 2011-03-09 | — | — | EP | disclosed |
| EP-2289556-A2 | Pharmaceutical composition for use in treatment of diabetes | Takeda Pharmaceutical Company Limited (JP) | 2011-03-02 | — | — | EP | disclosed |
| US-20110034518-A1 | Pharmaceutical composition | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2011-02-10 | — | — | US | disclosed |
| US-7842706-B2 | Pharmaceutical composition | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-11-30 | — | — | US | disclosed |
| US-20100029724-A1 | SCREENING METHOD | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2010-02-04 | — | — | US | disclosed |
| US-20090246232-A1 | Pharmaceutical composition | TAKEDA PHARMACEUTICAL COMPANY, LIMITED | 2009-10-01 | — | — | US | disclosed |
| US-7595333-B2 | Agent for improving acidosis | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-29 | — | — | US | disclosed |
| US-7547710-B2 | Fused heterocyclic compounds as peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-16 | — | — | US | disclosed |
| US-7538125-B2 | Pharmaceutical composition | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-26 | — | — | US | disclosed |
| US-6121294-A | REDUCING THE AMOUNT OF THERAPEUTIC AGENTS ADMINISTERED TO A DIABETIC PATIENT BY ADMINISTERING AN INSULIN SENSITIVITY ENHANCER IN COMBINATION WITH AN ALPHA-GLUCOSIDASE INHIBITOR AS SAID THERAPEUTIC AGENTS; SIDE EFFECT REDUCTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| US-6103742-A | ADMINISTERING TO SAID PATIENT A THERAPEUTICALLY EFFECTIVE AMOUNT OF AN INSULIN SENSITIVITY ENHANCER IN COMBINATION WITH A STATIN COMPOUND TO TREAT DIABETES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-08-15 | — | — | US | disclosed |
| US-6080765-A | ADMINISTERING TO A MAMMAL FOR TREATING LIPID METABOLISM DISORDERS AN INSULIN SENSITIVITY ENHANCER WITH AN ALPHA-GLUCOSIDASE INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-06-27 | — | — | US | disclosed |
| WO-2000000195-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DIABETES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-01-06 | — | — | WO | disclosed |
| US-5965584-A | insulin sensitivity enhancer such as pioglitazone in combination with a biguanide such as metformin | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-12 | — | — | US | disclosed |
| US-5952356-A | TREATING DIABETES IN A MAMMAL WITH AN ACTIVE MATERIAL AND A GLUCOSIDASE INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| EP-0479822-B1 | THERAPEUTIC NUCLEOSIDES | WELLCOME FOUND (GB) | 1999-08-18 | — | — | EP | disclosed |
| EP-0861666-A2 | Pharmaceutical composition for use in treatment of diabetes | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-09-02 | — | — | EP | disclosed |
| EP-0839801-A2 | Production of benzophenone derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-06 | — | — | EP | disclosed |
| EP-0749751-A2 | Pharmaceutical composition for use in tteatment of diabetes | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-12-27 | — | — | EP | disclosed |