Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.54 |
| ▸ | AXL | P30530 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.49 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.49 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | WNT1 | P04628 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2473158 | 0.84 | AXL (0.52) | AXLMAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL4225769 | 0.84 | MAP2K4 (0.47) | TRPA1AXLMAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL2469031 | 0.84 | AXL (0.55) | AXLMAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL1663211 | 0.83 | AXL (0.60) | AXLMAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL13854966 | 0.83 | MAP2K4 (0.73) | TRPA1AXLMAPK1MAP2K4MAPKAPK2 | |
| Hydrochloric Acid SCHEMBL27750634 | 0.83 | AXL (0.54) | AXLMAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL4006856 | 0.81 | AXL (0.55) | AXLMAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL14516332 | 0.80 | AURKA (0.59) | AXLMAP2K4AURKAHTR2AHTR2C | |
| SCHEMBL1663041 | 0.79 | AXL (0.50) | AXLMAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL3137122 | 0.79 | MAP2K4 (0.48) | TRPA1AXLMAPK1MAP2K4MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966151-B1 | POLYCYCLIC INDAZOLE DERIVATIVES THAT ARE ERK INHIBITORS | SCHERING CORP (US) | 2011-10-05 | — | — | EP | disclosed |