Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | MAP2K4 | P45985 | 6/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.51 |
| ▸ | MAPKAPK3 | Q16644 | 4/20 | 0.51 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.51 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.50 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2469031 | 0.90 | AXL (0.55) | AXLFGFR1FGFR2HTR2AHTR2C | |
| SCHEMBL4006856 | 0.90 | AXL (0.55) | AXLFGFR1FGFR2HTR2AHTR2C | |
| SCHEMBL31423230 | 0.89 | DCLK1 (0.65) | AXLHTR2AHTR2CHTR2BAURKA | |
| SCHEMBL4008208 | 0.89 | DCLK1 (0.65) | AXLHTR2AHTR2CHTR2BAURKA | |
| SCHEMBL12193658 | 0.89 | MKNK1 (0.61) | AXLFGFR1FGFR2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL27750634 | 0.88 | AXL (0.54) | AXLFGFR1FGFR2HTR2AHTR2C | |
| SCHEMBL1663652 | 0.86 | FGFR1 (0.68) | AXLFGFR1FGFR2HTR2AHTR2C | |
| SCHEMBL4009086 | 0.85 | AXL (0.55) | AXLHTR2AHTR2CHTR2BMAP2K4 | |
| SCHEMBL1664137 | 0.85 | LRRK2 (0.58) | AXLFGFR1FGFR2HTR2AHTR2C | |
| SCHEMBL1663819 | 0.85 | FGFR1 (0.71) | AXLFGFR1FGFR2AURKAMAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243324-A1 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2014-08-28 | — | — | US | disclosed |
| EP-2642994-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | Ligand Pharmaceuticals Incorporated (US) | 2013-10-02 | — | — | EP | disclosed |
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2012068406-A2 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243324-A1 | USE OF HEMATOPOIETIC GROWTH FACTOR MIMETICS | HGF, EPOR, MPL | AXL 1200/4885FGFR1 129/4885FGFR2 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.