Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 6/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | NEK2 | P51955 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3841951 | 0.89 | MAPT (0.78) | MAPTSMN1; SMN2KMT2APOLBMET | |
| SCHEMBL4129601 | 0.87 | MAPT (0.69) | MAPTSMN1; SMN2KMT2APOLBMET | |
| SCHEMBL2470365 | 0.83 | MAPT (0.77) | MAPTSMN1; SMN2KMT2APOLBMEN1 | |
| SCHEMBL2470591 | 0.83 | MAPT (0.77) | MAPTSMN1; SMN2KMT2APOLBMET | |
| SCHEMBL1949173 | 0.83 | MAPT (0.70) | MAPTSMN1; SMN2KMT2APOLBMET | |
| SCHEMBL14494768 | 0.81 | MET (0.50) | MAPTSMN1; SMN2KMT2APOLBMET | |
| SCHEMBL4134359 | 0.79 | MAPT (0.64) | MAPTSMN1; SMN2KMT2APOLBMET | |
| SCHEMBL3117740 | 0.78 | MAPT (0.58) | MAPTSMN1; SMN2KMT2APOLBMET | |
| SCHEMBL3117728 | 0.78 | MAPT (0.58) | MAPTSMN1; SMN2KMT2APOLBMET | |
| SCHEMBL13247060 | 0.77 | MET (0.70) | MAPTSMN1; SMN2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960370-B1 | PYRIDIAZINONE DERIVATIVES FOR TUMOUR TREATMENT | MERCK PATENT GMBH (DE) | 2011-10-05 | — | — | EP | disclosed |