Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 11/20 | 0.88 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1218492 | 0.89 | PTGER4 (0.82) | PTGER4POLBSMN1; SMN2 | |
| SCHEMBL2432735 | 0.86 | PTGER4 (0.72) | PTGER4CNR1CNR2 | |
| SCHEMBL2433523 | 0.85 | PTGER4 (0.68) | PTGER4ALOX15L3MBTL1CNR1CNR2 | |
| SCHEMBL1219231 | 0.85 | PTGER4 (0.66) | PTGER4L3MBTL1KDM4EPOLBRXFP1 | |
| SCHEMBL24273393 | 0.83 | PTGER4 (0.64) | PTGER4SMN1; SMN2CNR1CNR2GSK3B | |
| SCHEMBL3428359 | 0.83 | PTGER4 (0.66) | PTGER4POLBCNR1CNR2 | |
| SCHEMBL16341822 | 0.82 | PTGER4 (0.64) | PTGER4ALOX15L3MBTL1ABCB1POLB | |
| SCHEMBL1218939 | 0.81 | PTGER4 (0.61) | PTGER4L3MBTL1KDM4EPOLBMAPK1 | |
| SCHEMBL16341865 | 0.81 | PTGER4 (0.66) | PTGER4POLBSMN1; SMN2CNR1CNR2 | |
| SCHEMBL16340925 | 0.81 | PTGER4 (0.63) | PTGER4POLBCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101977655-A | Indazole derivatives | PFIZER | 2011-02-16 | — | — | CN | claimed |
| US-20110028447-A1 | INDAZOLE DERIVATIVES | PFIZER INC. | 2011-02-03 | — | — | US | claimed |
| EP-2265335-A1 | INDAZOLE DERIVATIVES | Pfizer Inc. (US) | 2010-12-29 | — | — | EP | claimed |
| WO-2009106982-A1 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | claimed |
| CN-101977655-A | Indazole derivatives | PFIZER | 2011-02-16 | — | — | CN | disclosed |
| US-20110028447-A1 | INDAZOLE DERIVATIVES | PFIZER INC. | 2011-02-03 | — | — | US | disclosed |
| US-20110028447-A1 | INDAZOLE DERIVATIVES | PFIZER INC. | 2011-02-03 | — | — | US | disclosed |
| US-20110028447-A1 | INDAZOLE DERIVATIVES | PFIZER INC. | 2011-02-03 | — | — | US | disclosed |
| EP-2265335-A1 | INDAZOLE DERIVATIVES | Pfizer Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009106982-A1 | INDAZOLE DERIVATIVES | PFIZER INC. (US) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028447-A1 | INDAZOLE DERIVATIVES | CNR1, CNR2, GPR119 | PTGER4 359/4885ALOX15 1599/4885L3MBTL1 3518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.