Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 7/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12197869 | 0.92 | SMN1; SMN2 (0.72) | GRM4SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL1972335 | 0.80 | NPC1 (0.74) | GRM4SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL12197865 | 0.78 | KMT2A (0.71) | GRM4SMN1; SMN2NPC1TP53ALDH1A1 | |
| SCHEMBL15408951 | 0.77 | NPC1 (0.74) | GRM4SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL935075 | 0.77 | NPC1 (0.70) | GRM4SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL1869494 | 0.75 | F13A1 (0.69) | SMN1; SMN2ALDH1A1KDM4EMAPT | |
| SCHEMBL12197835 | 0.75 | NPC1 (1.00) | GRM4SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL15408665 | 0.75 | NPC1 (0.72) | GRM4SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL15406717 | 0.74 | NPC1 (0.69) | GRM4SMN1; SMN2RAB9ANPC1TP53 | |
| SCHEMBL12197830 | 0.74 | GRM4 (1.00) | GRM4SMN1; SMN2RAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110243844-A1 | SULFONAMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | MERCK SHARP & DOHME CORP. | 2011-10-06 | — | — | US | disclosed |
| US-20110243844-A1 | SULFONAMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | MERCK SHARP & DOHME CORP. | 2011-10-06 | — | — | US | disclosed |
| WO-2010033350-A1 | SULFONAMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | MERCK & CO., INC. (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110243844-A1 | SULFONAMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | GRM4, GRIA4, GRM1 | GRM4 1/4885SMN1; SMN2 790/4885RAB9A 1746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.