Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | NAMPT | P43490 | 3/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | TNF | P01375 | 2/20 | 0.55 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12197868 | 0.92 | GRM4 (0.68) | SMN1; SMN2MAPTALDH1A1KDM4EGRM4 | |
| SCHEMBL12010892 | 0.81 | SMN1; SMN2 (0.78) | SMN1; SMN2MAPTALDH1A1KDM4ETSHR | |
| SCHEMBL12197865 | 0.78 | KMT2A (0.71) | SMN1; SMN2MAPTALDH1A1GRM4TSHR | |
| SCHEMBL1865395 | 0.78 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTALDH1A1KDM4ETSHR | |
| SCHEMBL20380257 | 0.76 | SMN1; SMN2 (0.70) | SMN1; SMN2MAPTALDH1A1KDM4ETSHR | |
| SCHEMBL20385512 | 0.76 | NAMPT (1.00) | SMN1; SMN2MAPTALDH1A1KDM4ETSHR | |
| SCHEMBL29882281 | 0.76 | MAPT (0.62) | SMN1; SMN2MAPTALDH1A1KDM4ETSHR | |
| SCHEMBL20389438 | 0.76 | MAPT (0.62) | SMN1; SMN2MAPTALDH1A1KDM4ETSHR | |
| SCHEMBL1972335 | 0.75 | NPC1 (0.74) | SMN1; SMN2MAPTKDM4EGRM4LMNA | |
| SCHEMBL20657330 | 0.75 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110243844-A1 | SULFONAMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | MERCK SHARP & DOHME CORP. | 2011-10-06 | — | — | US | disclosed |
| US-20110243844-A1 | SULFONAMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | MERCK SHARP & DOHME CORP. | 2011-10-06 | — | — | US | disclosed |
| WO-2010033350-A1 | SULFONAMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | MERCK & CO., INC. (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110243844-A1 | SULFONAMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | GRM4, GRIA4, GRM1 | SMN1; SMN2 790/4885MAPT 1712/4885ALDH1A1 3825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.