Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CRBN | Q96SW2 | 7/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN4A | P35499 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrantoin SCHEMBL79518 | 0.93 | TSHR (0.54) | TSHRTDP1CRBNAKR1B1DDB1 | |
| Tetrantoin SCHEMBL29582305 | 0.93 | TSHR (0.54) | TSHRTDP1CRBNAKR1B1DDB1 | |
| SCHEMBL409009 | 0.80 | TSHR (0.47) | TSHRTDP1CRBNAKR1B1DDB1 | |
| SCHEMBL16659357 | 0.80 | TSHR (0.42) | TSHRTDP1CRBNAKR1B1PDE7A | |
| SCHEMBL12199728 | 0.80 | TSHR (0.42) | TSHRTDP1CRBNAKR1B1MAPT | |
| SCHEMBL30667158 | 0.78 | TSHR (0.50) | TSHRTDP1CRBNAKR1B1DDB1 | |
| SCHEMBL7923379 | 0.77 | PDE7A (0.44) | TSHRTDP1CRBNAKR1B1DDB1 | |
| SCHEMBL573359 | 0.77 | CRBN (0.41) | TSHRTDP1CRBNAKR1B1DDB1 | |
| SCHEMBL16659358 | 0.76 | ALDH1A1 (0.53) | TSHRTDP1CRBNDDB1PDE7A | |
| SCHEMBL8775591 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296750-B2 | Spirolactam CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-03-29 | — | — | US | disclosed |
| US-20150111914-A1 | SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-04-23 | — | — | US | disclosed |
| US-20110245240-A1 | CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245240-A1 | CGRP RECEPTOR ANTAGONISTS | CCKAR, CALCRL, QRFPR | TSHR 325/4885TDP1 3318/4885CRBN 3154/4885 |
| US-20150111914-A1 | SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, TACR1 | TSHR 762/4885TDP1 2415/4885CRBN 3488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.