Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.47 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.47 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764662 | 0.83 | POLB (0.68) | MAPTALDH1A1L3MBTL1TAAR1HDAC3 | |
| SCHEMBL10916539 | 0.83 | MAPT (0.63) | MAPTALDH1A1L3MBTL1TAAR1HPGD | |
| SCHEMBL17963199 | 0.81 | ALDH1A1 (0.79) | MAPTALDH1A1L3MBTL1TAAR1HPGD | |
| SCHEMBL9764567 | 0.81 | MAPT (0.61) | MAPTALDH1A1L3MBTL1TAAR1HPGD | |
| SCHEMBL1409656 | 0.81 | MAPT (0.66) | MAPTALDH1A1L3MBTL1TAAR1HPGD | |
| Hydrochloric Acid SCHEMBL10945993 | 0.81 | MAPT (0.61) | MAPTALDH1A1L3MBTL1TAAR1HPGD | |
| SCHEMBL7049647 | 0.81 | MAPT (0.60) | MAPTALDH1A1L3MBTL1TAAR1TUBB4A | |
| SCHEMBL5775605 | 0.80 | MAPT (0.59) | MAPTALDH1A1L3MBTL1TAAR1HPGD | |
| SCHEMBL8251271 | 0.80 | KMT2A (0.63) | MAPTALDH1A1L3MBTL1TAAR1HPGD | |
| SCHEMBL1066727 | 0.80 | MAPT (0.59) | MAPTALDH1A1L3MBTL1TAAR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1702920-B1 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMA (US) | 2011-10-12 | — | — | EP | disclosed |
| EP-2264028-A1 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-22 | — | — | EP | disclosed |