Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3276057 | 0.84 | HTT (0.49) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL5216741 | 0.84 | HTT (0.49) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL3740451 | 0.84 | HTT (0.49) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL943039 | 0.83 | POLB (0.42) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL28094431 | 0.83 | POLB (0.38) | POLBLMNAL3MBTL1HTT | |
| SCHEMBL7300215 | 0.82 | POLB (0.41) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL1530965 | 0.82 | SMN1; SMN2 (0.46) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL4491733 | 0.82 | SMN1; SMN2 (0.46) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL1031700 | 0.82 | SMN1; SMN2 (0.46) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL16129826 | 0.82 | POLB (0.41) | POLBSPHK1SCN3AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107158398-A | The MetAP2 inhibitor and its treatment method of application of polymeric conjugation | 辛德弗雷克斯公司 | 2017-09-15 | — | — | CN | disclosed |
| CN-107141410-A | The MetAP2 inhibitor and its treatment method of application of polymeric conjugation | 辛德弗雷克斯公司 | 2017-09-08 | — | — | CN | disclosed |
| EP-2374454-A1 | Hemiasterlin derivatives and uses thereof in the treatment of cancer | Eisai R&D Management Co., Ltd. (JP) | 2011-10-12 | — | — | EP | disclosed |