Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1362567 | 0.82 | ACE (0.43) | LMNASMN1; SMN2 | |
| SCHEMBL943039 | 0.82 | POLB (0.42) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL12201786 | 0.82 | POLB (0.42) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL16948330 | 0.80 | POLB (0.41) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL4491733 | 0.80 | SMN1; SMN2 (0.46) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL1031700 | 0.80 | SMN1; SMN2 (0.46) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL16129826 | 0.80 | POLB (0.41) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL1530965 | 0.80 | SMN1; SMN2 (0.46) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL15665432 | 0.79 | POLB (0.39) | POLBSPHK1SCN3AMAOAMAOB | |
| SCHEMBL9150599 | 0.79 | POLB (0.39) | POLBSPHK1SCN3AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378690-A | Treatment of angiotensin induced hypertension | SANKYO COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0274259-A2 | New renin-inhibitory oligopeptides, their preparaton and their use | Sankyo Company Limited (JP) | 1988-07-13 | — | — | EP | disclosed |