Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 3/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12203881 | 0.86 | CYP4F2 (0.40) | CYP4F2CYP4A11MC4RALDH1A1GAA | |
| SCHEMBL6800028 | 0.86 | CYP4F2 (0.39) | CYP4F2CYP4A11ALDH1A1GAALMNA | |
| SCHEMBL10134601 | 0.82 | CYP4F2 (0.37) | CYP4F2CYP4A11ALDH1A1GAATDP1 | |
| SCHEMBL13265175 | 0.81 | CYP4F2 (0.42) | CYP4F2CYP4A11ALDH1A1GAALMNA | |
| SCHEMBL13263963 | 0.80 | CYP4F2 (0.40) | CYP4F2CYP4A11ALDH1A1GAALMNA | |
| SCHEMBL6798291 | 0.78 | CYP4F2 (0.39) | CYP4F2CYP4A11MC4RALDH1A1GAA | |
| SCHEMBL12202110 | 0.77 | CYP4F2 (0.38) | CYP4F2CYP4A11ALDH1A1GAALMNA | |
| SCHEMBL12202901 | 0.76 | IDO1 (0.41) | ALDH1A1GAALMNAMAPTTSHR | |
| SCHEMBL3906109 | 0.75 | CYP4F2 (0.53) | CYP4F2CYP4A11ALDH1A1GAATDP1 | |
| SCHEMBL12202857 | 0.74 | CYP4F2 (0.39) | CYP4F2CYP4A11ALDH1A1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2374794-B1 | CYCLIC AMINE COMPOUNDS | DAIICHI SANKYO CO LTD (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-2374794-A1 | CYCLIC AMINE COMPOUNDS | Daiichi Sankyo Company, Limited (JP) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010074088-A1 | CYCLIC AMINE COMPOUNDS | 第一三共株式会社 (JP) | 2010-07-01 | — | — | WO | disclosed |