Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12203066 | 0.86 | GCK (0.54) | SMN1; SMN2NPC1RAB9ATP53ALDH1A1 | |
| SCHEMBL12461221 | 0.83 | NPC1 (0.58) | SMN1; SMN2NPC1RAB9ATP53KDM4E | |
| SCHEMBL84506 | 0.82 | L3MBTL1 (0.52) | KDRBRAF | |
| SCHEMBL2635471 | 0.82 | NR3C2 (0.47) | SMN1; SMN2NPC1RAB9ATP53KDM4E | |
| SCHEMBL12203143 | 0.82 | NR3C2 (0.40) | SMN1; SMN2NPC1RAB9ATP53GAA | |
| SCHEMBL12203144 | 0.82 | JAK2 (0.52) | SMN1; SMN2ALDH1A1MAPK1KMT2ANR3C2 | |
| SCHEMBL5029364 | 0.81 | NR3C2 (0.59) | NR3C2 | |
| SCHEMBL12203072 | 0.80 | MAPK1 (0.47) | SMN1; SMN2NPC1RAB9ATP53MAPK1 | |
| SCHEMBL12203075 | 0.80 | MAPK1 (0.47) | SMN1; SMN2NPC1RAB9ATP53KDM4E | |
| SCHEMBL12203146 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034811-B2 | Hydroxamic acid esters and pharmaceutical use thereof | LEO PHARMA A/S (DK) | 2011-10-11 | — | — | US | disclosed |
| US-20070244117-A1 | Novel Hydroxamic Acid Esters and Pharmaceutical Use Thereof | LEO PHARMA A/S (DK) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244117-A1 | Novel Hydroxamic Acid Esters and Pharmaceutical Use Thereof | F9, F12, HDAC9 | SMN1; SMN2 4242/4885NPC1 2834/4885RAB9A 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.