Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 7/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 3/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1615659 | 0.88 | AGER (0.62) | AGERHTR2AMCHR1CHRM1DRD2 | |
| SCHEMBL1283731 | 0.83 | AGER (0.68) | AGERDRD2DRD4DRD3 | |
| SCHEMBL1284058 | 0.80 | AGER (0.70) | AGERHRH3 | |
| SCHEMBL1283724 | 0.80 | AGER (0.70) | AGERHRH3 | |
| SCHEMBL1615682 | 0.78 | AGER (0.62) | AGERHTR2AMCHR1CHRM1DRD2 | |
| SCHEMBL12649489 | 0.77 | AGER (0.78) | AGER | |
| SCHEMBL12203951 | 0.77 | AGER (0.48) | AGERHTR2AMCHR1CHRM1ESR1 | |
| SCHEMBL18649947 | 0.76 | AGER (0.62) | AGERDRD2DRD4DRD3HRH3 | |
| SCHEMBL1615200 | 0.75 | AGER (0.57) | AGERDRD2DRD3HRH3 | |
| SCHEMBL12203990 | 0.74 | AGER (0.64) | AGERHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482931-B1 | MONO- AND BICYCLIC AZOLE DERIVATIVES THAT INHIBIT THE INTERACTION OF LIGANDS WITH RAGE | TRANSTECH PHARMA INC (US) | 2011-10-19 | — | — | EP | disclosed |