Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 5/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3740850 | 0.80 | AKT2 (0.70) | AKT2AKT1CHEK1CHEK2ABL1 | |
| SCHEMBL12203913 | 0.77 | AKT2 (0.50) | AKT2AKT1CHEK1CHEK2ABL1 | |
| SCHEMBL26953475 | 0.77 | AKT2 (0.50) | AKT2AKT1CHEK1CHEK2ABL1 | |
| SCHEMBL12204174 | 0.77 | AKT2 (0.50) | AKT2AKT1FEN1CHEK1CHEK2 | |
| Hydrochloric Acid SCHEMBL28973063 | 0.77 | AKT2 (0.67) | AKT2AKT1CHEK1CHEK2ABL1 | |
| SCHEMBL4859450 | 0.77 | MAP4K4 (0.56) | FEN1ALOX5APMAP4K4PIK3CAPIK3CG | |
| SCHEMBL18291404 | 0.77 | PIK3CD (0.52) | AKT2AKT1FEN1CHEK1CHEK2 | |
| SCHEMBL6196346 | 0.75 | — | — | |
| SCHEMBL30725521 | 0.74 | DHFR (0.47) | AKT2AKT1FEN1LRRK2PDPK1 | |
| SCHEMBL29638874 | 0.73 | AKT2 (0.56) | AKT2AKT1CHEK1CHEK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025076290-A1 | 5-6-5/6-BISARYL COMPOUNDS AS FLT3 INHIBITORS | PURDUE RESEARCH FOUNDATION (US) | 2025-04-10 | — | — | WO | disclosed |
| US-20230295144-A1 | 2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof | UNIV ZHEJIANG (CN) | 2023-09-21 | — | — | US | disclosed |
| US-11591325-B2 | 2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof | ZHEJIANG UNIVERSITY (CN) | 2023-02-28 | — | — | US | disclosed |
| US-20210284625-A1 | 2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof | UNIV ZHEJIANG (CN) | 2021-09-16 | — | — | US | disclosed |
| EP-3530657-A1 | 2-POLYSUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE AND PREPARATION AND MEDICAL USE | Zhejiang University (CN) | 2019-08-28 | — | — | EP | disclosed |
| WO-2018086546-A1 | 2-POLYSUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE AND PREPARATION AND MEDICAL USE | 浙江大学 | 2018-05-17 | — | — | WO | disclosed |
| EP-2229356-B1 | 1,2-DISUBSTITUTED-4-BENZYLAMINO-PYRROLIDINE DERIVATIVES AS CETP INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES SUCH AS HYPERLI PIDEMIA OR ARTERIOSCLEROSIS | NOVARTIS AG (CH) | 2011-10-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11591325-B2 | 2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof | CHEK1, PLK1, CHEK2 | AKT2 710/4885AKT1 821/4885FEN1 402/4885 |
| US-20230295144-A1 | 2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof | CHEK1, PLK1, CHEK2 | AKT2 710/4885AKT1 821/4885FEN1 402/4885 |
| US-20210284625-A1 | 2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof | CHEK1, PLK1, CHEK2 | AKT2 710/4885AKT1 821/4885FEN1 402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.