Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 19/20 | 0.82 |
| ▸ | GSK3B | P49841 | 19/20 | 0.82 |
| ▸ | CDK1 | P06493 | 18/20 | 0.82 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.82 |
| ▸ | CDK2 | P24941 | 3/20 | 0.82 |
| ▸ | AURKA | O14965 | 2/20 | 0.82 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.82 |
| ▸ | PAK4 | O96013 | 2/20 | 0.82 |
| ▸ | ABL1 | P00519 | 2/20 | 0.82 |
| ▸ | FYN | P06241 | 2/20 | 0.82 |
| ▸ | RET | P07949 | 2/20 | 0.82 |
| ▸ | KDR | P35968 | 2/20 | 0.82 |
| ▸ | CDK8 | P49336 | 2/20 | 0.82 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.82 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.82 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.82 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.82 |
| ▸ | CDC7 | O00311 | 1/20 | 0.82 |
| ▸ | PLK4 | O00444 | 1/20 | 0.82 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379047 | 0.90 | GSK3A (1.00) | GSK3AGSK3BCDK1MAPK8CDK2 | |
| Iodide SCHEMBL5618949 | 0.84 | GSK3A (0.60) | GSK3AGSK3BCDK1MAPK8CDK2 | |
| SCHEMBL3100624 | 0.84 | GSK3A (0.70) | GSK3AGSK3BCDK1MAPK8CDK2 | |
| SCHEMBL1778992 | 0.83 | GSK3A (0.62) | GSK3AGSK3BCDK1MAPK8CDK2 | |
| SCHEMBL1778374 | 0.83 | GSK3A (0.65) | GSK3AGSK3BCDK1MAPK8CDK2 | |
| SCHEMBL1778282 | 0.83 | GSK3A (0.58) | GSK3AGSK3BCDK1MAPK8CDK2 | |
| SCHEMBL1777115 | 0.82 | GSK3A (0.57) | GSK3AGSK3BCDK1MAPK8CDK2 | |
| SCHEMBL1778404 | 0.81 | GSK3A (0.59) | GSK3AGSK3BCDK1MAPK8CDK2 | |
| SCHEMBL12605936 | 0.81 | GSK3A (0.59) | GSK3AGSK3BCDK1MAPK8CDK2 | |
| SCHEMBL1777830 | 0.81 | GSK3A (0.59) | GSK3AGSK3BCDK1MAPK8CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110257190-A1 | CRYSTALLINE FORMS | SANOFI (FR) | 2011-10-20 | — | — | US | disclosed |
| US-20110251219-A1 | TREATMENT FOR GLOMERULONEPHRITIS WITH 2-[4-(7-ETHYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)PHENYL]PROPAN-2-OL | SANOFI (FR) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257190-A1 | CRYSTALLINE FORMS | SSB, PRNP, TTR | GSK3A 4291/4885GSK3B 4174/4885CDK1 1776/4885 |
| US-20110251219-A1 | TREATMENT FOR GLOMERULONEPHRITIS WITH 2-[4-(7-ETHYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)PHENYL]PROPAN-2-OL | REN, PA2G4, PMP22 | GSK3A 4777/4885GSK3B 4768/4885CDK1 3631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.